Maureen: Thought I'd share my husband's exp. since he's 69 and has had it l2 yr. His regimen involves presently, 600mg/day Sinimet Cr&l00st mixed l mg/day Cogentin ( something few have mentioned but has always helped the tremors ) l5 mg. Bromocriptine ( recently added as an agonist- taking it slow - seems to be helping some) I have a question to you- Why so much Sinimet? The most we've taken(my husband asks when I'm going to start my doses, har,har) is l000mg/day and work to minimize it. When he feels overdosed, there seems to be more difficulties symptomatic to PD. Sometimes we miss doses and seems to be better - but know we can't go to long with too little, but some variances help I think. Also, has he had a thyroid checkup for the possibilities of weight loss? Let me know, he's the first I've heard of on such high levels of Sinimet.... Blessed to be with you all... Marie