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On Thu 07 Jan, DAVID N+sandra n wrote: > > Subject: Fw: Help Sinemet balance > > > Day before yesterday I came down with a stomach virus. I take liquid Sinemet, 10/ > 100 mg. mixed in 1 litre of water with 1000 mg of Vitamin C daily. I could not keep t > he liquid Sinemet down. So therefore having had the disease for going into 19th year > my symptoms are advanced. I could do nothing for myself, bless my husband's heart , D > avid had to do everything for me. You see Sinemet is my miracle drug. It is the only > medicine that has ever helped me. When it loses its optimum efficiency the doctors ju > st change the form in which I take the Sinemet. > So far that has been effective. > > My question is, Does anyone have any ideas of how I could possibly keep the Sineme > t down? Or have any of you parkys had a similar experience? > > Your input in greatly appreciated, > Sandra Norris > Hello Sandra, It's nice to see someone in similar circumstances as myself doing well on Sinemet. I am 59, was diagnosed 20 years ago, and can trace my early symptoms back to 26 years ago. I am somewhat amazed that you can survive on just Sinemet (I take levodopa -the important part of Sinemet- in the form of Madopar Tablets, but in addition I take 4.5 mg of Permax ( or Pergolide as it is known in the UK. You obviously have excellent doctors ( neurologists, I assume) - I have not met one who would be capable of the delicate changes which you and I require. Don't lose them! Regarding your stomach virus, I have twice in the last 5 years allowed my chronic constipation to get to such a state that my digestive system simply stopped completely: For about 4 days, it was a case of nothing in, and nothing out! I was the same as you, totally dependant on my wife for dressing, standing up, sitting down etc. As far as miracle fixes go, I have two suggestions which may possibly help, although, as I don't know where you live, I cannot be sure that you can obtain the drugs which I will be mentioning. 1) Motillium (Domperidone) is an anti-emetic which is given to people who have difficulty in keeping Sinemet down in the early years. It is very effective in those circumstancec, but I would guess that if you really have a viral infection, neither the Sinemet nor the Motillium would stay down long enough to do any good. 2) Apo-morphine is cleared in the UK and Europe I believe. It would, I suppose, be categorised as a Dopamine agonist but the main point is that it is administered by subcutaneous injection, and so avoids the entire digestive system. It sounds ideal but... - Apomorphine was originally used as an emetic, which is not a good place to start! It is routinely taken with Motilium , and assuming that it stays down, would be worth trying. Other points: it is very fastacting, because it has a head start by its speedy access to the blood stream. However, for the same reason, each dose lasts roughly 45 minutes only, so if used continually, you would rapidly begin to look like a pin-cushion. I hope that was of some use: let me know how you get on. -- Brian Collins <[log in to unmask]>