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I have been suffering with leg cramps for the last 2 weeks. Nothing seems to help. In fact taking two Tylenol seems to relieve it as much as all that high powered arthritis medicine I have in my medicine cabinet. I have been blessed with osteoarthritis as well as my PD. For weeks now I have been spending a part of the night walking the floor trying to get the cramps out of my legs and feet. Then last week my hands decided to act up and draw my little finger and my thumb together. Doesn't sound so bad???? It hurt like H****!!!!! It looks like that old Dean Martin & Jerry Lewis movie where Jerry's hands draw up from him squeezing oranges for so long, and=20 he goes around saying "Occupational Disease" or something such as that. I'm getting ready to go back to work and I'm not even certain I can undo my "claws" to get them around the steering wheel, let alone drive. Hope something kicks in soon. =20 The only thing I can see that's any different in my life is the weather in Ft. Lauderdale is cold and damp. Well, 52=BA IS COLD down here. I take 750 mg . of Laradopa a day, as I have a Carbodopa intolerance. I'm sorry to be this bitchy, but this is how I feel this morning, after being up walking the floor since 3 a.m. Has this happened to anyone else, or am I out in cyberspace alone again??? As Ever, Marjorie, just another librarian with PD 66/10