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Hi List-- Thought I would add my experience to the rest re Tasmar. I'll give my neuro brownie points for promptness--no fool he when it comes to malpractice lawsuits. His sec'y /nurse? called me the day after the letter came out and said to stop taking it and to add more Sinemet if I needed. "Cold turkey?" I asked. She agreed. I was on the 100 mg 3x day regime and assumed it would be a piece of cake. Reluctantly, because it had really been the only drug I'd found to help reduce my Sinemet and people had been telling me I seemed much perkier, I put the pills in the closet. It hasn't been a disaster but it hasn't been fun. My balance went off; I was getting lots of festination; my knees felt weak; the time between pills, which had been stretched to 5 or 6 hours was back down to 4, if that; and my speech got ever more whispery. I've only had PD about 6.5 years, so I don't have any freezing yet. The timing was lousy--just before Christmas, with all the shopping and getting ready for family to come. I fell in the kitchen raising a humongous bruise on my thigh, and then just 2 days before company arrived, I fell in the garage hitting my face on the concrete floor and cutting my eyebrow and inside my mouth. Had a spectacular shiner for the holidays but am all healed up now. (BTW, I violated my own advice in my article about not pivoting and tripped over my own foot in the latter instance.) Somewhere along about 10 days into withdrawal, I called my neuro's office and told them to reactivate my Mirapex prescription (which I'd quit to start Tasmar). Now that I'm finally up to strength--,50mg 6x day--it's helping me but not like Tasmar did. And the sleep-shortened nights don't help my energy level either. This is not to complain, only report, but I 'll sign off with one plea--HURRY WITH THAT ENTACAPONE! Kathy Kunz, 63/ 94/92