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Good day, all. I would like to solicit comments on the effects of fatigue which PWP's experience. My wife Carline does reasonably well after rising in the morning and taking her Sinemet CR. As the day progresses, however, the Sinemet becomes less and less effective, even if the pills are taken at the normal, regular intervals. So in the afternoon she switches to the regular Sinemet and increases the frequency with which she takes it. Even though she does this, she becomes progressively more stiff as the evening progresses. By 10:00PM or so she can barely move, essentially regardless of how much Sinemet she takes. (She is not overdosed as we have tried in addition to the higher doses also lower doses). There is another curious effect which I have not seen discussed: Her face becomes flushed, red and her whole body seems to get very warm when this happens. The degree of "flushing" seems to be related directly how she feels. The worse she feels the redder her face. Comments please, Thanks, K-F Etzold (CG Carline)