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hi k-f At 12:06 99/01/15 -0500, you wrote, in part: >I would like to solicit comments on the effects of fatigue which PWP's >experience. My wife Carline does reasonably well after rising in the >morning and taking her Sinemet CR. since it can take an hour for controlled release sinemet to 'kick-in' this 'doing reasonably well' could be partly attributable to the so-called 'sleep benefit' and not to the sinemet cr >As the day progresses, however, the Sinemet becomes less and less >effective, even if the pills are taken at the normal, regular intervals. >So in the afternoon she switches to the regular Sinemet and increases >the frequency with which she takes it. Even though she does this, she >becomes progressively more stiff as the evening progresses. this sounds very much like an under-sinemetized state where carline's pd symptoms of rigidity and slowness are 'showing through' >By 10:00PM or so she can barely move, essentially regardless of how >much Sinemet she takes. (She is not overdosed as we have tried in >addition to the higher doses also lower doses). fine-tuning the pd benefits and the med side-effects can be very exacting have you tried keeping a detailed hour by hour diary as recommended by brian collins? >There is another curious effect which I have not seen discussed: >Her face becomes flushed, red and her whole body seems to get very >warm when this happens. The degree of "flushing" seems to be related >directly how she feels. The worse she feels the redder her face. i get the same thing when under-medicated! it may be connected to genes i am red-headed with freckles and my skin flushes easily hope this helps your and carline's cyber sibling janet [not a medico but a nosy parkie] janet paterson - 51 now /41 dx /37 onset - almonte/ontario/canada <http://www.newcountry.nu/pd/members/janet/index.htm> [log in to unmask]