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Just a few more observations on the meds wearing off, and the red face. I take Sinemet to boost me in the morning, then Sinemet cr and Mirapex during the day. When I am exercising or stressed, I have noticed the meds do wear off faster. I also get very flushed, to the point I was misdiagnosed with Lupus. I attribute the flush to pain, which causes my blood pressure to increase (both begin to increase as meds wear off). You might visit with your dr. about both. Bob 40/2mo/6yrs