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Gil Lieberman wrote: > > Dear Janet, > Thanks very much for the information on Apomorphine treatment of PWPs. > At our last meeting with Aliza's neurologist,Dr. Nir Giladi,head of the > Movement Disorders Section of the Tel Aviv Medical Center,he mentioned > the possibility of trying Apomorphine introduction by sniffing through the > nose with Aliza.Aliza's skin is so thin,injection through her skin would not > be practical.We did not ascertain where this research is being done.There was > no mention of this technique in the writeup you posted.Do you have any > information on this technique? > Gil Lieberman,CG for Aliza,75,2/95 The following review (from Current Science Reviews for July 1995, which should be in the list archives) fails to mention that the self-injection pen uses a tiny jet of very high pressure to force the drug through the skin without the damaging effect of a needle. The principal objection to this mode may be the cost, since with its short half-life, apomorphine alone must be taken frequently. The objection to oral administration has been its emetic property, and nasal spray has proven too irritating in some patients. A side effect in some male patients was pathological increase of libido, which required restraint measures in some cases. Altogether, apomorphine seems most useful either as a diagnostic tool or as a "rescue" from occasional unpredictable "off" episodes in PD. Ostergaard, L. et al: Jour Neur Neurosurg Psy 1995;58:681-687 Injections of apomorphine (normally an emetic for juvenile poisoning) by single-use pen, which patients can do themselves, in 14 PD patients (plus 8 placebo controls) reduced the duration and severity of "off" periods and improved the general feeling of well-being. Cheers, Joe -- J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks, CA 91403-5013