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Rick, If I'm not mistaken, L-tryptophan is one of the naturally occurring substances involved in the body's production of dopamine. At the advice a nutritionist, I took L-tryptophan tablets for several years, with no impact on my PD. When it failed to work, my nutritionist then wanted to add granulated lecithin, which--I think--is also involved in the natural prod. of dopamine. I bowed out at that point and ended my relationship with my nutritionist, for a variety of reasons, but who knows.....? I was uncomfortable with the fact that my nutritionist seemed to reach his conclusions alone, with minimal evidence. But it interests me that you have followed a similar path--or, I think you have: for all I know , there's no functional relationship between L-tryptophan and hydroxy tryptophan. And I invite anyone out there to correct any biochemical misinformation that I may have inadvertently conveyed . Rrick, I have had problems with early waking ever since I've had PD, and it seems to be pretty common. I take 2 sleeping meds and a good night is when I sleep 4-5 hours straight and then cat-nap until a reasonable time to get out of bed. Marty Polonsky