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> Barbara Blake-Krebs wrote: > > Gerry...You raise a good question when you ask what > > is in this drug to cause a patient to have increased > > rigidity/freezing when withdrawing the drug. I suspect that likely the drug attaches itself to liver tissues and the why's and how's are yet to be ascertained. I believe our neuro has just about taken all her patients off Tasmar which caused an occasional regressions such as with my wife. But I have been told that 2 or 3 of her patients have suffered toxic reactions to Tasmar, and it was decided that the risk/benefit ratio was not worth endangering lives. No one has been able to respond to the question I had with regard to reversing the toxic effect of Tasmar with immediate cessation of the drug upon noting a initial increase in the level of liver enzymes. Actually, a tightening of the dose schedule and a slight increase in the dosage of Sinemet, accompanied by a small daily dose of Ambien seemed to ease the regression. The addition of Ambien (a soporific) aids in stabilizing the medication. Michel Margosis