The X-Files:The Cause of PD is US! Is the incidence of Parkinson's and other neurological disorders on the increase around the world or is that just a perception? If these disorders are increasing in epidemic proportions, one wonders why. This essay attempts to put the pieces together as the drawer of the X-Files opens. Opening Scene: Mulder, looking older and using a cane is shuffling alongside of Scully, as they stroll down a tree covered path in the Spring. The grounds are that of the Brookhaven Medical Center. Scully: Mulder when did you first discover that you had young onset Parkinson's? Mulder: It was when I had the death struggle on the rock pile with the alien. As I was trying to stick the needle of the green stuff into his neck I noticed a tremor in my right hand and it was so intense that I lost grip on the syringe and lost it. Scully: I thought according to neuroepidemiology studies most Parkinson's occurs in rural settings. How do you think your's occurred? Mulder: Before my sister was abducted, we lived in a small rural community and mom had the nicest garden and Bossy the cow gave the richest milk. We always had fresh fruits and vegetables from the garden and homemade ice cream socials. My father remember worked for the "Smoking Man" doing some kind of research that he wasn't allow to talk about. Zoom Out...in the distance the "Smoking Man" is seen behind a tree lighting another cigarette..wearing a trench coat even though Mulder and Scully were in shirt sleeves. Scene II: The "Committee" is having a meeting attended by the "Alien" and the "Smoking Man". The "Leader" of the international "Committee" says: Leader: The time has come to wind down our associations with our "Friends" and set our operatives up to use the knowledge we have gained from Alamosa, our cloning, DNA alterations, and permanently close the X-Files. The "Leader" nods to the "Smoking Man", your President should be told to open the secret files about human experimentation with ionizing radiation so that we can develop a market for our technology to repair...at a price..what we collectively have done. The Russian, the Chinese, the Frenchman and the Pakistani nod in agreement. "Smoking Man": It will be done straight away! http://www.wpi.org/Initiatives/init/oct96/whereare.html Zoom Out: President Clinton is seen at a press conference announcing the opening of the records on human subjects used in ionizing radiation experiments. Scene III: A researcher is being interviewed as part of the debriefing part of the opening of the records. Debriefer: Doctor as part of the testing of nuclear devices wasn't it suspected that humans coming in contact with the products of a detonation could be harmed? Researcher: Well it wasn't really considered that the weather could play such an important part in increasing the area of contamination. We were doing it, the Russians were doing it and the Chinese...we had all we could do to keep up with the "genie" we had unleashed. Even thought later we would learn that those coming in contact with the products of the blast would forever be changed...the DNA challenged so much that neurologic disorders would occur in epidemic proportions 30 and 40 years down the road..we went ahead. Strontium 90 with a half-life of 29 years, loses its radioactivity slowly. It is also highly toxic because of its ability to mimic calcium in the body, becoming part of the bone marrow tissue and damaging blood-producing cells. It permeates soil and attaches to every living organism and its offspring eventually reaching man and his offspring. Scene IV: A epidemiology study is published on mortality in PD finds a North-South bias with an increased prevalence west of the Mississippi River in the US. Their findings closely resembled a map released by the National Cancer Institute. http://www.parascope.com/articles/1097/falloutfigure1.htm Closing Scene: Mulder and Scully are in Mulder's apartment. Mulder falls on his sofa like he has done many times before, his cane comes to rest on the coffee table. Scully pushes him over and sits beside him. Scully: Mulder with all this new revelations how do you explain the increased incidence of Parkinson's disease in the southern hemisphere? Most of the above ground nuclear testing has been done in the Northern Hemisphere. Mulder: Scully, we live in a closed environment here on earth, there have been nuclear tests in the southern Pacific and also in South Africa...those things have increased the risk in South America and also Australia. Again, it is the Strontium 90 getting into the food chain and then into man and the offspring that is causing the gene mutations. Until then it is business as usual. Scully will you pass me my Sinemet? Scully: How do you think the "Smoking Man" avoided getting Parkinson's? Mulder: Smokers since the 60s when the highest concentrations of Strontium 90 were in the atmosphere, have filtered their air through the cigarette filter by inhaling. Non-smokers draw unfiltered air into their lungs and mouth. The Japanese on the otherhand wear surgical masks when outdoors so that protects them. END http://www.bullatomsci.org/issues/1997/nd97/nd97ortmeyer.html All of the published works on epidemiology through interviews and examination of death records postulate that some unknown environmental factor is the cause of Parkinson's and it relates to location, habits and the environment. Until recently, the thought has been directed towards exposure to pesticides or herbicides and by drinking well water indicated that the respondents lived in a rural setting. The following are EPA records of Strontium 90 in milk. Radiation levels in pasteurized milk, 1960-1992 (annual mean exposure, in picocuries per liter) ------------------------------------------------------ Strontium-90 in Cesium-137 in Year pasteurized milk pasteurized milk ------------------------------------------------------ 1960 8.6 18.0 1961 8.0 11.0 1962 13.4 44.0 1963 23.5 108.0 1964 23.8 109.0 1965 17.6 58.0 1966 13.3 29.0 1067 10.2 16.0 1968 8.9 11.0 1969 7.5 9.0 1970 7.3 8.0 1971 6.8 9.0 1972 5.6 6.0 1973 4.4 5.0 1974 4.7 8.0 1975 3.9 9.0 Mov Disord 1990;5(4):322-4 The following observations could account in Russian and Chinese detonations of nuclear weapons, drifting onto the west coast of Canada, Washington and Oregon. Geographic distribution of deaths due to Parkinson's disease in Canada: 1979-1986. Svenson LW Department of Psychology, University of Alberta, Edmonton, Canada. Mortality figures for Parkinson's disease in Canada from 1979 to 1986 were examined by province and by sex. As seen in other studies, Parkinson's disease showed a statistically significantly higher prevalence in males than in females (p less than 0.01). An uneven distribution across provinces was found when mortality rates were compared by males and when males and females were grouped together. Females did not show a significant variation across provinces. Five provinces showed a higher incidence of Parkinson's disease among males than in females (p less than 0.05), whereas the other provinces showed no difference.British Columbia and Manitoba showed the highest rates for males as well as the highest rates when males and females were grouped together. The uneven geographic distribution of Parkinson's disease offers support for the possible involvement of environmental factors in the etiology of some forms of idiopathic Parkinson's disease. Suggestions for further research are outlined. PMID: 2259356, UI: 91080887 ---------- Neuroepidemiology 1990;9(5):243-7 Parkinsonism death rates by race, sex and geography: a 1980s update. Lilienfeld DE, Sekkor D, Simpson S, Perl DP, Ehland J, Marsh G, Chan E, Godbold JH, Landrigan PJ Division of Environmental and Occupational Medicine, Mount Sinai School of Medicine, New York, N.Y. To evaluate temporal changes in the geographic distribution of Parkinson's disease (PD) mortality in the United States, we reviewed death rates for PD in the nine regions of the United States for 1980-1984. Age-adjusted mortality for all ages and for the elderly (65 years of age and older) was analyzed.Variation in PD mortality was observed among the regions for all demographic groups. The patterns were different from those reported during 1959-1961.Changing geographic patterns in mortality provide evidence for an environmental etiology for PD. PMID: 2087248, UI: 91204105 ---------- Neurology 1988 Oct;38(10):1558-61 Parkinsonism death rates by race, sex, and geography. Kurtzke JF, Goldberg ID Neuroepidemiology Research Program, Veterans Administration Medical Center, Washington, DC 20422. Age-adjusted death rates for Parkinson's disease (PD) in the United States from 1959 to 1961 demonstrated significantly lower rates for blacks than for whites, with rates for Oriental Americans the same as for whites. All racial groups showed a male preponderance. Both whites and blacks had a similar excess of PD death rates for residents of the four northern census regions of the US over their rates for the three southern regions. Within each region the sex and race differences remained. Thus, blacks in the US appear to be "protected" against PD, but they share the north: south gradient seen for whites. Race, sex, and geography would therefore seem to be independent risk factors for PD, providing further evidence that this may then be an acquired, environmental disease. PMID: 3419598, UI: 88334911 Med Hypotheses 1989 Feb;28(2):75-9 Toxic waste used as fertilizers is taken up in the plants and fruits and when eaten, pass to the animal or human, challenging the DNA of the host and resulting in a mutation. Tomatoes and Parkinson's disease. Sage JI Department of Neurology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick 08903-0019. Recent developments have focused attention on the possibility that a toxic environmental factor may be the cause of Parkinson's disease (PD). A hypothesis seeking to explain the cause of PD must explain its worldwide distribution, the small percentage of the population affected, geographic variations in prevalence and why PD was unrecognized prior to the early nineteenth century. The difficulties in finding a ubiquitous environmental agent which could account for these observations, may be illustrated by considering the hypothesis that such an agent may be a constituent of a common plant such as the tomato. This hypothesis meets all the necessary prerequisites. It is testable and appears to be an excellent starting point from which to search for the cause of PD. PMID: 2927356, UI: 89181271 Can J Neurol Sci 1987 Feb;14(1):36-41 Ecogenetics of Parkinson's disease: prevalence and environmental aspects in rural areas. Barbeau A, Roy M, Bernier G, Campanella G, Paris S We make use of the unique combination of a homogeneous genetic and racial origin in the rural population of Quebec and the facilities of free and universal access to medical care, to study the distribution of the prevalence of Parkinson's disease in the 9 rural hydrographic regions of the Province. Through 3 different methods of ascertainment, confirmed by two control probes, we demonstrate that the prevalence of Parkinson's disease is of uneven distribution within rural areas. We further investigated the characteristics of the regions of high prevalence. These regions which are predominantly agricultural and areas of intensive market gardening were also the areas with the highest use of pesticides. PMID: 3815163, UI: 87130309 [log in to unmask] Search the parkinsn archive online at: http://james.parkinsons.org.uk Catch the Parkinsn List messages on line at: http://www.ionet.net/~jcott/homepage/archive/patp.html *NEW*Click the page ads and use the new search tools*NEW* John Cottingham