For Charles T Mayer, M. D.
Hello Charlie, you wrote previously :-
> Most movement disorder specialists I think- try to avoid
> Sinemet early in the disease because it can cause dyskinesia
> (random jersey movements) after several years of use but it is
> clearly the most effective drug.
I noticed that you omitted to say what your view is on this subject.
I, as you may be aware, am firmly wedded to the view that the cause
of so-called 'fluctuations' and apparently unpredictable switches of
symptoms from On to Off etc is caused simply by the fact that we continue
to lose dopamine cells, and the margin of tolerance gets smaller and
eventually reaches zero. This theory answers all known characteristics
without the need for some tenuous link (I have yet to see an explanation
of how it works) between early and late phases of PD.
Any thoughts ? Have you by any chance read the description of my 'Engineer's
Model of the brain and Sinemet?
http://james.parkinsons.org.uk
Regards,
--
Brian Collins <[log in to unmask]>
