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Hello again Parkinsn List: I just signed on 2 days ago and asked for anyone's experiences with Sinemet. Within 36 hours I'd received about 20 replys. Many thanks for your responses and encouragement. It is incredibly comforting to know that such a wealth of experiences, opinions and personalities are merely an e:mail message away. Your caring responses have definitely helped in alleviating some of my fears and given me a broader perspective on the issue of when to begin using Sinemet. Thanks again, Peter Williams