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I also understand that NAC (N-acetyl-l-cysteine) has been found to be very neuro protective in laboratory rats. Its available at GNC. I have been diagnosed for 11 years. I am 51. For the first two years I took Permax, Cogentin and Eldepryl. After two years I started Sinimet, kept the Permax and ditched the Cogentin. I worked as a middle manager in a specialty steel company for seven years after I was diagnosed. Intense fatigue was foremost among the symptoms that forced me onto disability. During the last several years of work, I had extreme difficulty keeping awake while driving. There were people driving while intoxicated that had better control of their automobile than I did. I continue to take Sinimet now and when my drugs are working I am in pretty good shape. But when they are not, I am not. At about the year nine years into the disease (7 years after starting Sinimet) I began to experience end dose wearing off. Gradually at first, but continually getting worse. This is a degenerative disease. For about the last year or so, I have had to pay more attention to my diet. Everyone's disease is different and yet the same. My personal experience with my employer was extremely positive. Only you can judge your employment situation but I think that I have heard many more supportive stories than not from people that have informed their employers. > -----Original Message----- > From: Parkinson's Information Exchange > [mailto:[log in to unmask]]On Behalf Of Phil Tompkins > Sent: Monday, February 01, 1999 2:13 AM > To: [log in to unmask] > Subject: Re: how long did sinemet work for you? >