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Joe, I thoroughly agree with your theory of dopamine depletion by stress and physical excerecie, even if it has positive qualities (broadly speaking stress, of any kind---i.e., positive or negative-- has the same effects on the immune and other systems involved in processing stress. Much of this is based on my personal experience. I've never tried taking an additional dose or accelerated dose, but that makes sense. I've had some success with timing my doses so that they fall shortly before I start exercising.