Just to share my husbands background for the past l2 yr. - the past 8 have inc. disturbed nights and we've tried various patterns of medication and have always gone back to dividing the Sinimet equally over the 24 hr. period. It always seemed reasonable to us that the body needs to maintain a level regimen of meds to deal with , even though the one middle of the night dose can be annoying(but he is usually up sometime near med time for a restroom break anyway). His neuro tried to compress the meds to daylight times only (3hr intervals), saying he really didn't need them when he sleeps, but, somehow the common- sense logic of that seemed off- We did try it though, with very poor results, -went back to the old standby regimen. Have you tried a 24 hr dosing regimen of whatever your meds are? He still exp. some stiffness and some minor leg cramps but generally sleeps real well . You'll find with time that PD battle is often one of trial and error. In trying new ways or meds we always kept in mind to go slow with changes, but don't be afraid to try variations to find out what works best for your system. (keep in mind, the Dr.s don't have all the answers and the more you get confidence in what you know works for you, the better you will feel) To be sure, there are bunches of PWP in your boat about the frustrations, just hang in there.....it can get better! Marie CG for husband 69/l2