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Callie M. Judd wrote: > > Just to share my husbands background for the past l2 yr. - the past 8 have > inc. > disturbed nights and we've tried various patterns of medication and have > always > gone back to dividing the Sinimet equally over the 24 hr. period. It always > seemed > reasonable to us that the body needs to maintain a level regimen of meds to > deal > with , even though the one middle of the night dose can be annoying(but he is > usually up sometime near med time for a restroom break anyway). > His neuro tried to compress the meds to daylight times only (3hr > intervals), > saying he really didn't need them when he sleeps, but, somehow the common- > sense logic of that seemed off- We did try it though, with very poor results, > -went > back to the old standby regimen. > Have you tried a 24 hr dosing regimen of whatever your meds are? He > still exp. > some stiffness and some minor leg cramps but generally sleeps real well . > You'll > find with time that PD battle is often one of trial and error. In trying new > ways or > meds we always kept in mind to go slow with changes, but don't be afraid to > try > variations to find out what works best for your system. Not only does a uniform level of medication help to avoid the painful "end-of-dose" dystonia and peak-dose dyskinesia, there is some research evidence that it is healthier for the surviving natural sources of dopamine. Joe -- J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks, CA 91403-5013