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Bob and list,

Bob Fink kindly reminds me of an inadvertent omission in my post on Parkinsonism. There is a
condition called tardive dyskinesia which can occur in patients on long-term neuroleptic treatment
usually for schizophrenia. This condition resembles dyskinesia many of us get with Sinemet.  It can
be at times irreversible even after the precipitating meds have been withdrawn.  It is a risk with
neuroleptics but is not related  specifically to PD symptoms.  It is thought to be the result of
receptor supersensitivity.

Thanks Bob for that addition.

Charlie
"Robert A. Fink, M.D." wrote:

> > From:          "Charles T. Meyer, M.D." <[log in to unmask]>
> > Subject:       Re: Parkinsonism
> > To:            [log in to unmask]
>
> > side effect dystonia and rigidity.  This is a REVERSIBLE condition which often responds to
> > cogentin or in some cases  the drug needs to be discontinued in order for the symptoms to go
>
> Charlie,
>
> They are not *all* reversible.  Don't forget tardive dyskinesia.
>
> Best,
>
> Bob
>
> ***********************************
>
> ROBERT A. FINK, M. D., F.A.C.S.
> Neurological Surgery
> 2500 Milvia Street  Suite 222
> Berkeley, CA  94704-2636  USA
> Phone:  (510) 849-2555   FAX:  (510) 849-2557
>
> WWW:  <http://www.dovecom.com/rafink/>
>
> mailto:[log in to unmask]
>
> "Ex Tristitia Virtus"
>
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--
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Charles T. Meyer,  M.D.
Middleton (Madison), Wisconsin
[log in to unmask]
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