Our neurologist says he has never seen such extremes of ON/OFF before. My husband, when he is ON can walk normally, speak clearly, use the computer, make a sandwich etc. etc. When he is OFF he is in bed, completely immobile, cannot speak and has great difficulty breathing.He is OFF up to 80% of the day. I would like to know if there is a clinic where he could be observed/ analysed over a period of several days to try and come up with some explanation for such variations. He is taking Sinemet 25/100 every 2 hours and has been diagnosed 9 years. Any information would be most welcome. Maureen Dorney for Ron,67.