Hi all ,
Very interesting.... so depending on the type of the symptom (if
tremors,freezing,pseudo-fatigue,dystonia, etc.) , or combination of some,the
effect of the extra dopamine will be quite different .
In my on case with mild tremor I do not notice any improvement with the
additional extra dose before exercises ( I still play soccer).I ought to make
further observations from now on to weight the effect of all variables besides
fatigue such as for instance emotional stress and others.
As pointed by Johnston et all , it seems to be related to the interplay of the
different neurotransmitters (endomorphine , adrenaline, dopamine etc. ) and the
causes of the symptoms.
Cheers ,
Joao Paulo
will johnston wrote:
> COMMENTS IN TEXT +++++++++ ++++++++
>
> ----------
> From: Will A. Kuipers <[log in to unmask]>
> Date: Saturday, February 06, 1999 4:38 PM
>
> Marty Polonski and Will Johnnston seem to agree with Joe Bruman's theory
> and
> advice to William A. Parrette that exercise will "use up" available
> dopamine
> and that it would not be harmful to take a little additional dopamine to
> offset the loss.
> I beg to differ.
> In my experience, not only exercise will cause an increase of tremor, but
> any kind of stress, or exitement, like getting up in a crowd and speaking,
> will do that.
>
> +++++++Some of us are freezers, others have tremors, some have both
> I have little tremor but lots of freezing. I find that stress can help
> with freezing.
> When driving, if a danger appears ahead my foot goes right to the brake
> with
> no hesitation or bradykinesia. My voice is generally better when speaking
> to a
> crowd than otherwise.++++++
>
> I would say, any cause that may increase the release of adrenalyn in the
> bloodstream will have that effect. Stopping the exercise or taking away the
> other causes is enough for the tremor to subside. I don't think the
> dopamine
> is "used up"; it is just otherwise occupied.
>
> +++++++++Adrenalin /epinepherin can act as a neurotransmitter / agonist.
> There are lots of stories of frozen PD patients who hear fire alarms or see
>
> smoke and outrun most people getting out. This may cause those with tremor
> as the major problem with PD to get an uncontrolled overload and
> tremor.++++++
>
> I don't see that taking extra dopamine will help much, because of the time
> it needs to take effect.
> ++++++++++Extra levodopa does require time to break down to dopamine. I am
> one of the PD patients whose PD symptoms worsen temporarily after taking a
> dose of levodopa [Sinemet] but improve tremendously when the medication
> becomes available as dopamine in the brain.+++++++
>
> A good example is when I try to turn around in bed. The effort causes a
> sudden flare-up of tremor which stops as soon as I quit struggling.
> Supposedly,according to the theory that is the time when there should be
> some dopamine in reserve! Not that I can notice!
>
> ++++++++Is this in the morning or during the night? Just after going to bed
> or
> longer if you have insomnia you have not produced much. I understand that
> we use
> little dopamine while sleeping but still build some while sleeping. As the
> PD
> progresses, our storage ability decreases. I'm afraid that my ability to
> store while
> I snore is not as good as it used to be..Alas!...++++++++++
>
> It would be interesting to investigate the interplay of adrenalyn and
> dopamine under controlled conditions. ++++++yes++++++
>
> Will A. Kuipers Dallas, Texas 78 / 71 / 70
> <[log in to unmask]>
--
+----| Joao Paulo de Carvalho |------ +
| [log in to unmask] |
+--------| Salvador-Bahia-Brazil |------+
