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hi all At 21:13 1999/02/13 -0500, sherry wrote, in part: >This morning I took my first SInemet CR 50/200 at about 9 with >breakfast. At 11:30 I became extremely nauseaus and had to go to bed >not being able to move a muscle without feelling like I was going to >throw up. Later I developoed a Migraine. Now I'm afraid to take >another Sinemet. Could the Sinemet have caused my problems or was >it a coincidence?... i would venture an educated guess that the sinemet doseage level is the culprit here is this the very 'first time' you've taken sinemet? if so, i'm surprised that your neuro did not recommend very low and slow 'titration' i.e. adjusting the doseage level very gradually up sinemet is infamous for causing stomach upset for the first weeks or months of using it the cr version, i.e. controlled release, would have the added 'benefit'?? of causing nausea slowly and constantly for at least 4 hours when i first started sinemet i took a half tab [i.e. 5/50] of an 'instant' 10/100 twice a day for a week, and then bumped it up to three times a day for another week, etc.... [the cr version was not available then] titrating sinemet is a basic fact of life with pd 200 mg [the largest size it comes in] as a 'first taste' strikes me as almost sadistic! if i were in your shoes i'd verify the titration rate with my neuro how many other parkies does your doctor treat? at what stages of the disease? we have to be our own best advocates we have to learn about pd in our own self defense this kind of [to my mind] sloppy prescribing of brain altering chemicals is too common still and can be [and has been] health threatening janet janet paterson - 51 now /41 dx /37 onset - almonte/ontario/canada <http://www.newcountry.nu/pd/members/janet/index.htm> [log in to unmask]