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Dear Gil, To the best of my knowledge, B12 doesn't have a direct effect on PD. However, B12 requires stomach acid in order to be absorbed; with aging, less of this acid is produced, and older adults often become depleted of B12 for this reason. B12 depletes slowly, sometimes over a period of years; and signs of depletion mimic Alzheimer's dementia well enough that people have been misdiagnosed as having Alzheimer's when it was actually B12 deficiency. I often counsel my clients to use either a multivitamin (such as Centrum Silver) or a B-complex supplement, taken separately from Sinemet (the amount of B6 in many B-complexes can be sufficient to block levodopa absorption). Good luck with your research! Best regards, Kathrynne Gilmour Luckham wrote: > Before i start sifting thru 20,000 sites on the Web, is there anyone out > there who can shed a bit of light on the effects ( good or bad ) of Vitamin > B12 on Parkinsons' ?? -- Kathrynne Holden, MS, RD "Nutrition you can live with!" Medical nutrition therapy http://www.nutritionucanlivewith.com/ Tel: 970-493-6532 // Fax: 970-493-6538 "If we knew what it was we were doing, it would not be called research, would it?" -Albert Einstein