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Yes Marty I am a proven fact that with Liquid Sinemet there is a marked difference in the frequency of dyskinesia and the severity of dyskinesia. I am 38 and have had pd going into my 19th year. Considering that I had the disease 8 years before I was properly diagnosed my neuros immediately started me on Sinemet. It is the only drug that is an effective treatment for me. After taking Sinemet for quite some time and in many different miligrams I started developing violent dyskinesia that was non productive and very painful. The options given to me were a drug holiday or Liquid Sinemet. I have been on liquid now for 3 1/2 years and with the help of Mirapex I am remarkably at the same dosage of Sinemet as when I first started taking it. Yes there are things that interfere with efficiency and that is my monthly cycle. That is it. In order to go through a drug holiday I would have to be admitted into critical skilled wing at the hospital. I loved the option of liquid Sinemet a lot better. I f there are any questions feel free to contact me. In the raging battle against Pd., Sandra 38/28/20 -----Original Message----- From: Marty Polonsky <[log in to unmask]> To: [log in to unmask] <[log in to unmask]> Date: Tuesday, February 09, 1999 5:01 PM Subject: Re: Avoiding Sinemet >I'd like to add my additional two cents worth to this ongoing dialogue. >Several neuro's have explained to me that dyskinesia is due to the uneven >dosing of sinemet vs. the more continuos, fluid absorption of dopamine in the >brain. If that's accurate, then PWP's who take liquid siniemet >theoretkically should have less trouble with dyskinesia. To my knowledge, >this has not been addressed. This theory does not explain when or under what >conditions dyskinesia is likely to occur in the PD process. >By the way.. I'm not an engineer--which is probably obvious to you. I am a >psychologist, with soma background in brain structure and function, and an >appreciation of systems theories. >Marty Polonsky