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Brian, Let me toss a few other tidbits into the stew--1) It is my understanding that during a typical meds cycle (focusing on sinemet, of course) we PWP's go from being undermedicated to overmedicated at peak dosage and back to undermedicated. 2)"Normals" have tens of thousands more dopamine producing neurons than we do, so why don't they become dyskinetic? the answer must lie in the pacing, or rate of absorption of dopamine by the cells in the substantia nigra. Strictly speaking, then, we PWP's are susceptible to dyskinesia not because we have more dopamine in our systems than "normals" but because we absorb dopamine at a faster, more uneven rate in the substantia nigra than "normals". I think we're both trying to say this same thing but with slightly different words. Another thing I find interesting about this theory is the implication that although "normals" have so much more dopamine producing capacity than we do, apparently they use only a fraction of it. abd possibly in other parts of the brain. MMMarty