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Dear Joe, Thanks to you and to all who've sent me information on Lewy Body Disease -- it's been a great help, and I've passed it on to my colleague as well as saving it in my own files. This list is a wonderful resource!! Best regards, Kathrynne "J. R. Bruman" wrote: > > For Kathrynne and others who may be interested in DLBD: Here are > 4 references from my CSR files, which are also in the Parkinsn > list Archives: You can get abstracts from Medline, but if this > is sufficient, it's probably easier to locate. (Sorry to be late > with this- my ISP is going nuts and I couldn't log on.) > > Hely M et al; J Neur Neurosurg Psy 1996;60:531-538: > Diffuse Lewy body disease (DLBD) looks like PD at first but also > includes dementia, either at onset or later in progression. > > Albin R et al; Neur 1996;47:462-466: > Six demented patients were studied by FD-PET, which can show local > distribution of dopamine metabolism, and CAT scan. Five of the six > showed some clinical signs of PD, and two who responded to levodopa > were so diagnosed. On autopsy later, all six were found to have > Diffuse Lewy Body Disease, a condition much more pervasive and > disabling than PD. Five of the six reported visual hallucinations, > and the two diagnosed with PD while living were distinct in having > "cognitive fluctuations". Despite past impression, apparently > FD-PET failed to distinguish DLBD from PD. > > Louis E et al;Neur 1997;48:376-380: > While Lewy bodies are always present in PD, some consider PD to be > a distinct member of a family of Lewy-body diseases. Authors > believe, for example, that up to 88% of diffuse Lewy-body disease > (DLBD) cases are misdiagnosed as PD. To test the hypothesis, they > analyzed clinical signs of 31 pathologically (postmortem) verified > DLBD cases and 34 similarly studied PD cases. There were no > differences in rigidity, bradykinesia, dystonia, or gaze palsy, > but DLBD cases had older onset, more common myoclonus, less common > rest tremor, and less common response to or perceived need for > levodopa. Any one of the last 4 signs is 10 times more likely to > indicate DLBD. > > Litvan I et al; Arch Neur 1998;55:969-978: > Presence of Lewy bodies is no longer considered essential to > diagnosis of PD, and there is some question as to whether PD and > dementia with Lewy bodies are two distinct diseases or not. The > authors had 6 neurologists review clinical records of a diverse > cohort, and compared their opinions with autopsy findings. > > -- > J. R. Bruman (818) 789-3694 > 3527 Cody Road > Sherman Oaks, CA 91403-5013 -- Kathrynne Holden, MS, RD "Nutrition you can live with!" Medical nutrition therapy http://www.nutritionucanlivewith.com/ Tel: 970-493-6532 // Fax: 970-493-6538 "If we knew what it was we were doing, it would not be called research, would it?" -Albert Einstein