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Hi Barb,

Barb_MSN wrote:

> possibly do, would cause you GREAT physical harm, or maybe WORSE!
> Post-pallidotomy, one CAN usually reduce the drug dosage, however,
> that should be done gradually, and in small amounts.I was able to
> reduce the daily dose of Sinemet by about 1/4th of what
> I took prior to the pallidotomy, and have pretty much been able to
> stay right at that reduced level since then.
>
> -----Original Message-----
> From: Joao Paulo Carvalho <[log in to unmask]>
>
> >Brian Collins wrote:
> >
> >>  I have always felt a little sensitive about the fact that my
> Model
> >> defines dyskinesia as being the result of the Dopamine level
> exceeding
> >> a critical value, and perhaps getting to synapses which were not
> the
> >> original target, thus sending the electrical message to the wrong
> muscles.
> >>
> >> My point is that I can produce plausible explanations for most of
> the
> >> phenomena which we associate with dyskinesias (including the
> dreaded
> >> Di-phasic Dyskinesia)

> >How to explain the fact that in SOME well done Pallidoctomy
> (destroying some
> >brain cells and neurons) there happens a elimination of the tremors
> and a
> >reduction or even the elimination of the need of  taking levodopa ??

Barb , the point I was to trying to get across was how to explain that
destroying more dopamine producer neurons (and other brain cells) with
Pallidoctomy the result is then,  paradoxically , the reduction of the
need of the intake of levodopa .(remembering that the culprit of the
symptoms is attributed to the shortage of dopamine in the brain)

Cheers ,

   +----| Joao Paulo de Carvalho   |------ +
   |         [log in to unmask]     |
   +--------| Salvador-Bahia-Brazil |------+