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Hello Brian , Brian Collins wrote: > On Wed 10 Feb, Joao Paulo Carvalho wrote: > > Barb , the point I was to trying to get across was how to explain that > > destroying more dopamine producer neurons (and other brain cells) with > > Pallidoctomy the result is then, paradoxically , the reduction of the > > need of the intake of levodopa .(remembering that the culprit of the > > symptoms is attributed to the shortage of dopamine in the brain) > > > Hello Joao Paulo, Your e-mail above tells me that you are missing one > important point in the story of Pallidotomy: The object of a Palidotomy > is not to damage brain cells (although a few may be accidentally damaged) > and it is certainly not to damage Dopamine-producing cells. The site > where all the Dopamine for the control of the major parts of our body > is the Substantia Nigra, and the Pallidotomy aims to partially sever > a bundle of nerve fibres in the Globus Pallidus (hence the name). My > way of explaining it is that the operation 'turns down the volume' of > the feedback nervous systen (All control systems require a feedback loop > to tell the main motor system how it is progressing). In a PWP's brain, > this return signal is swamping the output signal. I hope this helps, > Brian Collins <[log in to unmask]> Interesting to know that Brian because until then I had the impression that the area ( or path ) would be in which there were a blockage ,else a over firing , in the flux of the neurotransmitters and so causing the symptoms .Could this be possible to occur ?? Also to the best of my knowledge referring your statement " (although a few may be accidentally damaged) " I think Pallidoctomy aims to destroy some specific and particular brain cells in the Pallidus zone. Warm regards , -- +----| Joao Paulo de Carvalho |------ + | [log in to unmask] | +--------| Salvador-Bahia-Brazil |------+