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---------- > From: Sharon & Jim LeBlanc <[log in to unmask]> > To: [log in to unmask] > Subject: One Pathway where many things can go wrong to cause Parkinson's Disease > Date: Wednesday, February 17, 1999 10:49 AM > > < means decrease of substance > > means increase of substance > > URIC ACID > protects against PD > XANTHINE Potent cAMP phosphodiesterase > inhibitor > (GENE - Parkinsons produces too much > cAMP) > > XANTHINE OXIDASE - converts hypoxanthine to xanthine to > uric acid > HYPOXANTHINE helps make adenosine monophosphate > (AMP) > ADENOSINE 5' (n-ethylcarboxamide) Potent cAMP phosphodiesterase > inhibitor > (GENE - Parkinsons produces too much > cAMP) > > Adenosine infusion reduces substance P in cerebrospinal fluid. cAmp is > related to CREB related to dopamine. cAMP responsive gene proenkephalin is > part of the D2 receptor. Dopamine-receptor activation is related to CREB > phosphorylation. > > PERTUSSIS - inhibits the G-protein, causing loss of its function > and overproducing cAMP phosphodiesterase. It also causes Parkinson's > disease. > > > NAD - Nicotinamide adenenine dinucleotide is found in the retina. > 4-HNE or 4-hydroxy-2-nonenal is also found in the retina. It is a product > of lipid peroxidation. It causes a point mutation and defect of blue color > vision, tritanopia, a Parkinson's symptom. > (GENE - 4HNE causes Parkinson's disease) > U-101033E works against 4-HNE and MDA or Malondialdehyde and will help > PD. > > NICOTINE is found in tobacco and tea, both protect against PD > Nicotine is the N part of NAD > Diethyldithiocarbamate or nicotine relates to n-ethylcarboxamide I believe. > Haven't found the proof yet. > Sodium diethyldilithiocarbamate is related to Carbaryl, a pesticide. > > Carbaryl or 1-napthyl methylcarbamate is a wide spectrum insecticide which > controls over 100 species of insects on citrus, fruit, cotton, forests, > lawns, nuts, ornamentals, shade trees as well as poultry, livestock and > pets. It works whether ingested into the stomach of the pest or absorbed > through direct contact. It is available ad bait, dust, wettable powders, > granules, dispersions and suspensions. It is moderately to very toxic, > effects the nervous system. It affects cell division and chromosomes in > rats. > > Urethate or ethyl carbamate is a good solvent for organic materials, a > co-solvent for pesticides, fumigants, medications (VET), ANESTHETICS, > HYPNOTICS, SEDATIVES, diuretic solubilizer and co-solvent for cosmetics. It > is a co-solvent agent in textile treatments, an anti-neoplastic agent, used > as a component with quinine of sclerosing solutions, as a topical > bactericide. It is colorless and odorless. > > Urethane is a co-solvent for pesticides, like rotenone that is NADH > sensitive and has been shown to cause Parkinsons Disease. > > Normally, after the approptiate response is accomplished, cholinesterase is > released which breaks down acetylcholine, terminating the stimulation of > muscle. If acetylcholinesterase is unable to break down or remove > acetylcholine, the muscle can continue to move uncontrollably. > > Any pesticide can bind or inhibit cholinesterase, making it unable to > breakdown acetylcholine. The two main inhibiting pesticides are > organophosphates and the carbamates. Some newer chemicals, such as the > chlorinated derivatives of nicotine can also effect the cholinesterase > enzyme. > > Overexposure to organophosphate and carbamate insecticides can result in > cholinesterase inhibition (EXTONET). > > Just my theory, but maybe a little nicotine raises n-ethylcarboxamide and > prevents Parkinsons, but too much carbamates either mutates or destroys > n-ethylcarboxamide and causes Parkinsons. I'm not a chemist. > > NADH - Co Q10 > > NADH DEHYDROGENASE (COMPLEX I) > Defect in Parkinson's disease (1993) > (Rotenone) - UQH2 (Ubiquinone) - FAD ( flavoprotein fragment of NADH) > See Biochemical Pathways Map No O9 P9 > > FAD - < Glutathione Reductase - < Glutathione - Protects against Lipid > Peroxidation > Parkinsons is too much lipid peroxidation, these are too low. > (GENE - glutathione or glutathione reductase) > FAD - < glutathione reductase - < alpha lipoic acid < dihydrolipoic acid - > < chelation of free metals > < ability to decarboxylate dopa to dopamine > (EDTA or chelation therapy preserves glutathione reductase) > FAD- < Thioredoxin that thiolates glutamate synthase, peroxide reductase, > nitrite reductase > > glutamate, peroxide, nitric oxide (too much) > FAD - A2Red - <P450, which is inhibited by 4-HNE, < CYP2D6 > Responsible for protecting the body against toxins, hebicides, > and through which 60% of all medications are metabolized. > > (GENE) - CYP2D6 - Parkinsons > (GENE) - NDUFV2 - NADH mutation Parkinsons > (GENE) - NADH- ubiquinone oxioreductase depends on GRRed or > glutathione reductase > (GENE) - APOE4 - Apolipoprotein - Too little lipids, too much > peroxidation - Parkinsons > (GENE) - Alpha Synuclein - > Threonine - > lipid peroxidation - > Parkinsons > > <Glutathione Peroxidase - > superoxide radicals - >SOD2 or superoxide > dismutase two > >SOD2 - >Manganese and Increased Manganese intake causes Parkinsons > (GENE) - SOD2 > > >metals ->RHO - >Phospholipase D - >PIP2 - >IP3 - >Diacyglycerol - > >Arachidonic Acid - >Phospholipase A which opens up the calcium channels. > > >diacyglycerol would inhibit Protein Kinase C which phosphorylates B > vitamins, especially B6 > B6 deficiencies give you a lot of Parkinsons symptoms > <B6 - <NIFS that chelates metal sulfur clusters. Can't break them up. Lewy > Bodies. > > <NADH - Complex I - <Ubiquitin E2-25K - <HIP2 - <Huntingtin -<Dynactin p150 > or p50 -< CKAP - <Beta ACTIN - <NF/Y growth factor - (NFKB1 - Proteasome > 26S) > > Stem cell stimulation stimulates OCT4 fibroblast growth factor, stimulates > POU, stimulates NFKB1 or Nuclear Factor Kappa B1. > > (GENE) CCAAT binds to beta actin. > > [log in to unmask]