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Hi Philip , Another evidence that points that it is NOT a shortage of dopamine (levedopa) that is the main cause o the symptoms of PD is the observation that a DBS (deep brain stimulation) performed with success in a right point in the brain , do eliminate , or reduce substantially , these symptoms as well can also eliminate or reduce the need of the intake of levodopa . Unlike Pallidotomy , the DBS does not destroy some cells in a specific point in the brain but achieve the same results related to the elimination of the symptoms in PD. Philip Connors wrote: > [log in to unmask] writes: > > << IT is an interesting idea that pallidotomy is the cutting of a > > overactive movement feedback loop . It might explain PD freezing as > > an overactive feedback . > I can see why this second type, positive feedback, could be used in modeling > tremors. Electronically, this is Oscillator Theory and the next step is to > look at the "gain" of the system -- the state of the response to your meds > (amount of dopamine present?) NOW as a physicist/engineer I am over my head > in the biology/physiology/pharmacology of the brain and will stop here. > > You have just received the intro to a part of my Electronics course on Control > and Oscillators -- doesn't that make you want to rush back to college and > study physics and engineering -- or some of the other fun things that go on > there. It does for sure . :-)) Cheers, +----| Joao Paulo de Carvalho |------ + | [log in to unmask] | +--------| Salvador-Bahia-Brazil |------+