Hi Alastair and Philip , Good news then . These scan patterns may be an evidence that it is NOT the lack of dopamine responsible for a better flux (activities) distribution in the brain and having as consequence the reduction and even the elimination of the PD symptoms . Another consideration to take in account concerned with the use of levodopa ( aiming his transformation in dopamine ) is the fact that some drugs such as morphine ( used to reduce and even eliminate pains caused in some cancers for instance ) looses gradually their effect and demand to raise the intake of the drug continuously up to a situation where bad side effects have to limit this continuous increase of the drug. So it seems that for some drugs - that do act in the brain - there is a reaction by the whole system by getting used to them and diminishing their initial strong effects (as time goes by with the continuous intake) . Alastair Wyse wrote: > HI Joao > > I am under impression that some explanation may derive from such a > > research .It would show any modification of the flux in the area of > > activities inside the brain (before compared with the after). Does > > someone in the list knows that this has already been done ? > > Scans showing the pattern of blood flow in the brain before and after > Pallidotomy are different have have already been done . The > difference was considerable . IT affected the whole brain not just > the the pallidus . Best , +----| Joao Paulo de Carvalho |------ + | [log in to unmask] | +--------| Salvador-Bahia-Brazil |------+