Hi Joan, Harold had several months where he was trying different things (Mirapex, Tasmar) and became very weak, paranoid and had hallucinations. I can't separate out what caused which symptoms, but here's some excellent news: right now he is better than he has been for a year! Last spring he was in a wheelchair all the time, had significant cognitive deterioration, was afraid to stay alone even for a few minutes, never slept at night. I thought I would go crazy too! Today he seldom uses the wheelchair, is perfectly reasonable to talk to and sleeps all night! The best thing we learned from this is that *all* bad times are not permanent, even though the disease is degenerative. Here are the things that fixed him up: -- Dropped all the new fancy drugs - went back to tried-and-true sinemet and parlodel. -- 3 teaspoons of Chloral Hydrate at bedtime. We tried other sleeping meds but this is by far the best - the other ones let him wake up after a few hours. -- Using a condom catheter at night so he had no need to get up -- Paxil (40 mg) daily for depression -- Seroquel (25 mg) daily for paranoia -- Daily attendance at an adult day care center. Not only is he a different man than he was last year, I'm a different woman. I really thought, for a while there, my life was over. I stayed home from work for a month because he kept calling me, crying, needing me to come home. I feel so hopeful now - I've got some independence back AND I sleep all night!! Best of all, my partner is a real partner again. Good luck: keep your spirits up! Barbara Baichtal cg Harold (59, 21)