Olá! Hello! I would like to exchange information's about the use of "ENTACAPONE" - commercial name "COMTAN" or "COMTESS" - regarding the results, side efects,personal experience and other information about the use of this new medicine for PD. I am a 57 years old man , with about 15 of levodopa. I am now on 5x1/2 tablet of regular "Madopar 250 mg" (200 mg levodopa + 50 mg benserazida ) and before sleep 1 "Madopar 125 HBS", the retard formula with 100 mg of levodopa (Madopar = Sinemet). Last year I was also with 3x100 mg of "Tasmar", with good results, but this "tolcapone" formula is now out of the market;There are are 10 days I am taking the alternative "ENTACAPONE / COMTAN", 5x1 tablet 200 mg a day at same time than regular Madopar. I feel better, with ± 20% reduction of levodopa, less "off" periods and better mobility, specially in bed. I am looking for the best way to take them; to dissolve both tablets in a glass of middle temperature mineral water, out of meals is probably a good solution. Wait for your news.JOSÉ EMail: [log in to unmask]