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I've been taking Sinemet and selegiline for almost 3 yrs and have been plagued by severe irregularity ever since. There was some minor sluggishness prior to the meds but nothing like now. Each increase in Sinemet required an increase in laxatives to stay regular. I started Tasmar last fall because my PD symptoms were worsening and was rewarded with a dramatic reduction in unwanted symptoms. However, it was necessary to double my laxative intake. Reducing the Sinemet and selegiline helped very little. I'm now taking powdered senna and lactulose daily with some Milk of Magnesia occasionally. All other laxatives have little or no effect in maintaining daily regularity. I am not seeking a list of laxatives to try as I've tried a lot and these get the job done and are relatively safe. I think my problem is more the meds, and not as much the PD. I even have trouble with aspirin. I'd like to know if others have experienced this particular drug side effect. And do the specs that list chronic constipation as a PD symptom say it's really from the drugs? Lou Waldorf Onset 57-58, dx 62, 65