Phil,
Re your post:
Date: Fri, 12 Mar 1999 01:24:05 -0500
From: Phil Tompkins <[log in to unmask]>
Subject: Neuroprotective Supplements,
the following information posted on this list by
Linda Carleton contains information on possible
harmful effects of N-Acetyl-Cysteine(NAC) which was
recommended by Dr, Lombard for PWPs.Linda's
father is a PWP who had negative reactions from NAC.
There have been studies however which showed benefits
of NAC for PWPs.One of them was here in Israel in the Neurology Dept. of
Beilenson Hospital.Aliza was taking NAC
but stopped after reading Linda's post.
This example highlights possible dangers in taking
supplements whose characteristics are not well-understood.
On the other hand a PWP faced with rapid deterioration
may feel that it is worth trying anything which might
help.
Gil Lieberman,CG for Aliza,75/dx 2/95
----------------
Date: Sun, 22 Jun 1997 02:38:33 -0400
From: Forrests Mom <[log in to unmask]>
Subject: Warning! Do not take NAC!
Hi! Folks, In everyones discovery that antioxidants are beneficial, one
warning exist!
Some biochemiists believe that NAC acts as as a precursor for glutathione
and
that taking extra glutathione should raise tissue glutathione levels. While
supplementing the diet with high doses of NAC may be beneficial in cases of
extreme oxidative stress, it may be an unwise practice in healthy individuals.
The reason? One study indicated that when NAC was given orally to 6 health
volunteers at a dose of 1.2 grams per day for 4 weeks, followed by 2.4 grams
per day for an additional 2 weeks, it actually increased oxidative damage by
acting as a pro-oxidant.
A long search to find why my father reacted to the NAC is over! Please
take caution with NAC, l-glutathione supplements are fine! Even supplements
containing l-cystine seem to be OK. But please becareful with the NAC!
Anyone supected of having diabeties should not take cystine or NAC.
My father does not have diabeties,but NAC has a reversed effect
(pro-oxidant), it can de-activate glutathione supplies! Not something we
want to do with Parkinson's disease. And somehow the researchers have
really goofed on this one.
And finally I dug up the reason in Kleinveld HA, Demacker PNM, and
Stalenhoef
AFH, Failure of N-acetylcystein to reduce low-density lipoprotein
oxidiazability in healthy subjects. Eur J Clin Pharmacole 43, 639-642, 1992.
Thank goodness the search is over, I just could not understand why my
dad reacted, so permitters, as I see it are off limits to anyone with
Parkinsons.
Best Wishes Linda Forrest's Mom
---------------------
Date: Tue, 24 Jun 1997 15:22:23 -0400
From: "Fred W. Schaffert" <[log in to unmask]>
Subject: Re: Warning! Do not take NAC!/Question??
I read your recent post re NAC and was a little confused re your
conclusion. Your brief summary of the abstract stated that NAC failed
to reduce oxidation of low-density lipoprotein. As I recall, that
oxidation may be related to heart disease. But my question is did the
article specifically mention gluthatione effects? Could you posssibly
post excerpts from the article??
The reason I ask is a recent abstract of an article published in Exp.
Neurol. 1966 stated that NAC in combination with vit.C prevented
dopamine apoptosis or cellular self-destruction.
Thanks
