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Hi Sue and Al; you wrote.... > List members: My wife,who has had parkinsons for 13 years, would > like to know if anyone else gets cramping toes in the morning and > after taking Sinemet? And if so what do they do to stop them???? SNIP I experience an end of dose cramping in my right foot (my PD side) that generally occurs first thing in the morning before my Sinemet has had an opportunity to kick in. I thought it might be related to taking my morning Sinemet at first since this is generally when I experience the cramping. However if I have my shower before taking my meds I still experience the cramping. If I forget my meds or am under a lot of stress this can and does also occur at other times of the day but is most apt to happen at the end of my meds. The cramping is a turning inward of my foot and a curling under of my toes (like clenching your fist, only an involuntary and often very painful toe clenching). I deal with this cramp by stretching my achilles tendon and by stretching the underside of my foot against a wall or a curb. When you are out walking and this cramp occurs you can get some instant relief by walking backwards. This is a trick I learned from George Lussier here on this list. Stretching on a daily basis is the best prevention. A good physiotherapist can help a lot here once they understand the problem. I wish you the best in dealing with your "cramped toes". All the best ............... Murray [log in to unmask]