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Hi, I've been in the TEMPO study, which is a drug study for an MAO type B inhibitor, much like Selegiline. I've been on open label with the dose still blinded; also, I'm taking Mirapex, barely 1.5 mg/day (had some dose limiting side effects, like sleepiness, but no orthostatic hypotension. I've haven't gotten a good response to Mirapex, and I feel, much as I would like to put off Sinemet (I'm 54, diag. a year ago, probably had it from about '89) that my symptoms are really getting in my way: tremor is essential, not resting, so it's not a problem, but the inability to do much with my right hand, and dragging my right side is getting to be too much. I'm concerned that trying another agonist like Requip will take forever (My titration experience with Mirapex was VERY LONG) and may not do any more, and may cause problems for nothing. I've read that it takes weeks or even months to get an adequate response from agonists. I've taken Mirapex, albeit in small increasing doses, since last Sept. and it hasn't done much. I suppose the PD could be outpacing the therapy also. Q: Does Sinemet take long to show a response? How tough is it to come off Mirapex (though maybe I shouldn't). Any strategies coming to mind on handling starting generic carbadopa/levodopa with/without Mirapex? I would be grateful for any response. Thanks! Ann