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NO- There is a chance that the bioequivalence of different generics in rare cases are different . I have not heard that regarding Carbidopa-levodopa. If you remain on the same generic then even that chance is just about eliminated. I am confident enough of that that I personally take generics. If your neurologist feels otherwise ask him why and if he feels strongly about it then go by his recommendation. Charlie "Fercho, Gordon" wrote: > Is there any evidence that the generic of Sinemet is not as effective as the > real thing? My neurologist hinted at that. > Gordon Fercho > New Email address is: [log in to unmask] -- ****************************************************************************************** Charles T. Meyer, M.D. Middleton (Madison), Wisconsin [log in to unmask] ******************************************************************************************