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From: "Sharon & Jim LeBlanc" <[log in to unmask]>
To: <[log in to unmask]>
Subject: Co Q10
Date: Mon, 8 Mar 1999 09:55:56 -0500
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Hi Judy, Nice job with the information. Co Q10 is only one piece of a big
complex called Complex I or NADH-Ubiquinone oxioreductase. Complex I is the
first step in the electron transport chain of mitochondrial oxidative
phosphorylation and is located within the mitochondrial inner membrane. It
accepts electrons from NADH and transfers them through a series of electorn
carriers to ubiquinone (Coenzyme Q10). The internal electron carriers of
Complex I include flavin mononucleotide (FMN) and 6 iron-sulfur clusters .
Rotenone, an herbicide, causes Parkinsons symptoms, is thought to interact
with the ubiquinone binding site.
OMIN #516000 Complex I, Subunit ND1; MTND1 .
NDUFV2 is a Complex I gene, polypeptide 24kD, and causes Parkinsons
disease. UQCRFS1 Human Rieske FE-S Protein is another gene mutation of
Complex I that causes Parkinsons. It is part of the 6 iron-sulfur clusters.
There are several complexes actually in this reaction. I am interested in
complex I and II. I am interested in information about NAD. My husband has
Parkinsons color blindness (tritanopia blue-yellow). He can never tell the
difference between blue and green. NAD Nicotinamide adenine dinucleotide
effects your eyes and NADH Nicotinamide dehydrogenase is part of complex
one. Nicotinamide-nucleotide adenylyltransferase is an enzyme that
catalyzes the transfer of the adenylyl moiety of adenosine triphosphate to
the phosphoryl group nmn to form NAD and pyrophosphate. B vitamins are
pyrophosphalated and are messed up in Parkinsons. Nicotinic acetylcholine
receptors contains an ion channel as a result of binding to acetylcholine
and initiates muscle contractions. Imidoesters form amides like
nicotinamide and are part of uric acid. People with high uric acid are less
likely to get Parkinsons. Complex I is NADH-ubiquione oxioreductase.
Complex II or succinate-ubiquione oxioreductase is an important enzyme in
both the tricarboxylic acid cycle (this is how viagra works) and the
aerobic respiratory chain of mitochondria, Complex I, II, III, IV ect. It
is specifically involved in succinate and carries electrons from FADH
flavin adenosine dehydrogenase to ubiquinone. Now in Parkinsons Disease the
FAD is not working right either. FAD connects to glutathione reductase, and
to A2Red and P450 or CYP2D6 and thioredoxin all of which are problems for
parkinsonians. And succinate becomes succinyl choline which relaxes
muscles and stops them from contracting, it is a cholinergic antagonist and
is not working either. Carbaryl is an insecticide that effects adenosine
monophosphate. Nicotine helps Parkinsonians. I'm wondering if the problem
really is the adenyl moiety of adenosine triphosphate? Or not enough
nicotinamide-nucleotide adenylyltransferase?
I guess I got long winded.
Could you pass this on to the group so maybe someone out there can figure
this out .
thanks. [log in to unmask]
