Sharon & Jim LeBlanc wrote: > Could you pass this on to the group so maybe someone out there can figure > this out . > thanks. [log in to unmask] > Hi Judy, Nice job with the information. Co Q10 is only one piece of a big > complex called Complex I or NADH-Ubiquinone oxioreductase. Complex I is the > first step in the electron transport chain of mitochondrial oxidative > phosphorylation and is located within the mitochondrial inner membrane. It > accepts electrons from NADH and transfers them through a series of electorn > carriers to ubiquinone (Coenzyme Q10). The internal electron carriers of > Complex I include flavin mononucleotide (FMN) and 6 iron-sulfur clusters . > Rotenone, an herbicide, causes Parkinsons symptoms, is thought to interact > with the ubiquinone binding site. > OMIN #516000 Complex I, Subunit ND1; MTND1 . > > NDUFV2 is a Complex I gene, polypeptide 24kD, and causes Parkinsons > disease. UQCRFS1 Human Rieske FE-S Protein is another gene mutation of > Complex I that causes Parkinsons. It is part of the 6 iron-sulfur clusters. > There are several complexes actually in this reaction. I am interested in > complex I and II. I am interested in information about NAD. My husband has > Parkinsons color blindness (tritanopia blue-yellow). He can never tell the > difference between blue and green. NAD Nicotinamide adenine dinucleotide > effects your eyes and NADH Nicotinamide dehydrogenase is part of complex > one. Nicotinamide-nucleotide adenylyltransferase is an enzyme that > catalyzes the transfer of the adenylyl moiety of adenosine triphosphate to > the phosphoryl group nmn to form NAD and pyrophosphate. B vitamins are > pyrophosphalated and are messed up in Parkinsons. Nicotinic acetylcholine > receptors contains an ion channel as a result of binding to acetylcholine > and initiates muscle contractions. Imidoesters form amides like > nicotinamide and are part of uric acid. People with high uric acid are less > likely to get Parkinsons. Complex I is NADH-ubiquione oxioreductase. > Complex II or succinate-ubiquione oxioreductase is an important enzyme in > both the tricarboxylic acid cycle (this is how viagra works) and the > aerobic respiratory chain of mitochondria, Complex I, II, III, IV ect. It > is specifically involved in succinate and carries electrons from FADH > flavin adenosine dehydrogenase to ubiquinone. Now in Parkinsons Disease the > FAD is not working right either. FAD connects to glutathione reductase, and > to A2Red and P450 or CYP2D6 and thioredoxin all of which are problems for > parkinsonians. And succinate becomes succinyl choline which relaxes > muscles and stops them from contracting, it is a cholinergic antagonist and > is not working either. Carbaryl is an insecticide that effects adenosine > monophosphate. Nicotine helps Parkinsonians. I'm wondering if the problem > really is the adenyl moiety of adenosine triphosphate? Or not enough > nicotinamide-nucleotide adenylyltransferase? -- Judith Richards, London, Ontario, Canada <[log in to unmask]> ^^^ \ / \ | / Today’s Research \\ | // ...Tomorrow’s Cure \ | / \|/ ```````