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.Joan Waterman wrote: When you take a 25/100 Sinemet every two > hours,there is no good time to eat! I guess your method of > fasting by one meal a day is probably the best way. > Anyone else have a better one? A trick that I and others here have found useful is to hold the (regular) Sinemet in your mouth for a few seconds before swallowing it. Evidence that, conventional wisdom notwithstanding, absorption takes place is the arrival of thick ropy saliva and/or runny nose and the disappearance of dystonia, exactly the same as you get from taking it the usual way. Cheers, Joe -- J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks, CA 91403-5013