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Brian, as usual you come to my aid! You have been so helpful so many times. I can't thank you enough for all that you have done for the folks on this list! I don't think we would ever had the knowledge about levadopa (which is of such fundamental necessity to us) without your extensive studies and writings. I just hope I can follow up on the information with more planning that I have done, so as to get maximum use from the meds and lessen these awful "off" times and dyskinesia. Ruth Clark