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I was diagnosed almost 5 years ago and at that time was started on three whole 25/100 Sinemet and 10 mg. eldepryl. When I learned anough to realize that the medication was excessive, I changed neuros and now am seeing a very good one (Dr. Michael Rezak, director of the Movement disorder department at Evanston hospital) But I don't see him until 4/8 and he is out of town right now. Currently, I take one-half tablets of Sinemet 25/100 4x/day, plus 5 mg. eldepryl and .5 mg of permax (3x/day). I have had mild dyskinesia on and off for a couple of years, but nothing serious. I do not have a tremor and have never had one. My shuffle etc. is pretty one-sided, but moving to both sides. My problem: within the last two weeks I have developed a wild dyskinesia which gets worse every day. It is primarily in my feet (more left than right) but my whole body is involved. I can't tell whether it is peak dose or end-of-dose or both. Taking the sinemet doesn't seem to help--nor does it make it worse. The dyskinesia begins when I wake up in the morning (I used to have a fairly PD-free early morning) and immediately is very bad. So far, I have no problems with dyskinesia during the night , although I sleep less and less. (I used to have Restless Legs Syndrome but the permax seems to have helped that alot). With this dykinesia I trip on everything around, I have twice stepped on the dog--and hurt her--and I knock over things in the path of both hands and legs. And, of course I am totally exhausted from it--and depressed. And it is at its worst when I am trying to concentrate.This is all totally new Anyone with some help on this very sudden onset? Or have I just been lucky so far? Do you think CR would help? Or less Sinemet altogether? Or more agonist? I have watched this list help many others and I hope you have some words of wisdom for me. I thank you in advance. Nancy Shlaes deGrazia 62/dx57/symptons 54