Dear Jane, Ideally Sinemet should be taken 30-60 minutes prior to meals. This is because protein in foods can block Sinemet absorption. It's important for the Sinemet to clear the stomach and enter the bloodstream ahead of the protein. A problem, however, for many people, is that Sinemet can cause nausea and/or vomiting, especially on an empty stomach. This problem usually resolves in a matter of weeks. Some possible solutions: 1) Take the Sinemet with some ginger ale or crystallized ginger, plus a few low-protein biscuits 2) Take the Sinemet with meals for the first few weeks, until the system has a chance to adjust. Then begin taking Sinemet 30 minutes prior to meals 3) If nausea is intractable, her physician may wish to prescribe Lodosyn (carbidopa) or other medication in addition to her Sinemet to reduce nausea. If constipation is a problem, it will be important for her to drink plenty of fluids and get as much fiber as possible, preferably from whole-meal foods, vegetables, and fruits. Prunes and prune juice contain a natural laxative; she might try a serving two or three times a week. My very best regards to you and your mother, Kathrynne > My mother is 75 and was just diagnosed with early stage Parkinson's last > week. > At the moment, we're working our way through as many information > services as we can. It's even the basic things like when she should take > her meds etc as no-one explained it to her and the drug information > sheet wasn't passed on by the pharmacy. -- Kathrynne Holden, MS, RD Medical nutrition therapy http://www.nutritionucanlivewith.com/ "We are living in a world today where lemonade is made from artificial flavors and furniture polish is made from real lemons." --Alfred E. Newman