At 13:52 22-3-99 -0800, ERVIN J MCCARTHY wrote:
>Does anyone on the list have information on Riluzole? I have been asked
to
>join a group study on the drug. I believe it is in third phase study.
I
>recall someone in the list had been involved in a previous group study.
Any
>information would be helpful. Thank you.
>
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Erwin,
Riluzole or Rilutex is an anti-glutamate. It diminishes the influence of
the neurotransmitter
glutamate,which has an activating role in the Striatum. They are by some
researchers
believed to be to active in PWP's and to have a crucial role in
dyskinesia especially
the leva-dopa induced ones. The nuclei in which the glutamates are most
activ are the same that
as are partly destroyed by pallidotomy. But it is not in the first place
because of
that aspect why trials are run. It has been proven to have a
neuroprotective effect
for ALS patients and that has in the first place attracted the Parkinson
researchers,
because it might have the same neuroprotective effect for PWP,s. I am not
sure but I
remember that for the trials to come, starting PWP's have been asked to
participate, so
the only outcome of the research will be about its neuroprotective
effect.
I regret that, because I am more interested in its potential
anti-diskinetic power.
Times New RomanNext to the mentoned
effects is Riluzole, if used in higher dosis a paini killer a
tranquiliser and an anti -convulsive.
With theses URL.s more info can be retrieved,
ida
http://parkinson.org/plll.htm
WWW.rorer.com/PATIENTS_FAMILIES/trials/trials.rilutek.htm
http://www.rpr.rpna.com/US/rilutek/ppi.html
http://www.druginfonet.com/rilutek.htm
http://neuro-www.mgh.harvard.edu/forum/ALSF/11.13.9812.56PMRilutek.html
http://www.rpr.rpna.com/health_professionals/diseaseaware/rilutek.htm
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Vriendelijke Groeten / Kind regards,
Ida Kamphuis mailto: [log in to unmask]
