Dear Donna, Diabetes is not uncommon in people with PD. His physician(s) should be aware that there is the possibility for false blood or urine glucose readings with levodopa. > My reasons for coming aboard here are numerous, but one thing that stands out > as an immediate question is: What is the specific experience of PD patients > who also have diabetes? Do they have unique complications that we should be > aware of? Timing of meals and medications is doubly important in people using diabetes medications and levodopa. Levodopa absorption is hindered by protein. Physicians often start patients off taking Sinemet with meals to decrease initial nausea; however, when this has stabilized, usually in a few weeks, Sinemet should be given 30 minutes prior to meals. It is true that Sinemet CR may be taken with meals, however this often takes longer to "kick in" and may not give as pronounced an effect. With regard to diabetes medications, these need to be taken as prescribed. My very best regards, Kathrynne -- Kathrynne Holden, MS, RD Medical nutrition therapy http://www.nutritionucanlivewith.com/ "We are living in a world today where lemonade is made from artificial flavors and furniture polish is made from real lemons." --Alfred E. Newman