Dear Rebecca: Your amount of meds may not be as excessive as the timing is. My husband has had experience with Sinimet CR and 25/250 and we are presently on the agonist Bromocriptine. (We asked our Neuro. about Permax and all he indicated was that he "didn't like Permax" but would give us a presc. for Mirapex if we felt it might be better than Bromo). He also used the Lorazipam to aid sleeping while we were making a stressful move, but he felt able to discontinue it as soon as he got comfortable in life style again. Your Dr. may know your symptoms and feel they require the frequency of the Sinimet - but what do you feel? My husband also takes Sinimet CR 800mg/day, distributed equally in 6 hr intervals( seems to work best for him though we've tried more frequent intervals at Dr. request and found difficulties). Lately, we have started to "pinch-hit" with Sinimet 25/l00 st ( as effective as the l/2 -25/250 we used some years ago). We only use the l00 Sinimets when the symptoms of dyskinesia show up, or he starts having freezing and rigidity due to end of dose times ( fluctuations he's only noticed starting the last few months- been diagnosed over l2 yrs. now) You will have to discover what works best for you - but generally it sounds like such an uncomfortable, busy pill-taking schedule to me. I would recommend you stay flexible in your attempts to find the best times and amounts give you the best results- We often have had to manipulate the planned and rigid regimen of doses "prescribed" and make it work for us. It takes patiance and sometimes endurance since the symptoms can fluctuate and be evasive about what the regular schedule should be , since it can take weeks to actually stabilize on adjusted amounts. Keep in mind, though, YOU KNOW YOU better than anyone and the rest of us can only encourage, share, and hopefully help..... Someone who cares........ Marie Care- Partner for husband