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Ervin, I'm in the open Label phase of the Baylor Univ Riluzole test. I can't put any eloquence around the experience, but I'd share. Lanny 56/53/Riluzole and recently Mirapex. ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ ERVIN J MCCARTHY wrote: > > Ida, thank you for your detailed response about Riluzole. I plan on > gathering as much information as I can before I enter a study group. > > -----Original Message----- > From: Ida & Andre Kamphuis <[log in to unmask]> > To: [log in to unmask] > <[log in to unmask]> > Date: Tuesday, March 23, 1999 11:17 AM > Subject: Re: RILUZOLE STUDY > > At 13:52 22-3-99 -0800, ERVIN J MCCARTHY wrote: > >Does anyone on the list have information on Riluzole? I > have been asked to > >join a group study on the drug. I believe it is in third > phase study. I > >recall someone in the list had been involved in a previous > group study. Any > >information would be helpful. Thank you. > > > >[log in to unmask] > > Erwin, > > Riluzole or Rilutex is an anti-glutamate. It diminishes the > influence of the neurotransmitter > glutamate,which has an activating role in the Striatum. They > are by some researchers > believed to be to active in PWP's and to have a crucial role > in dyskinesia especially > the leva-dopa induced ones. The nuclei in which the > glutamates are most activ are the same that > as are partly destroyed by pallidotomy. But it is not in the > first place because of > that aspect why trials are run. It has been proven to have a > neuroprotective effect > for ALS patients and that has in the first place attracted > the Parkinson researchers, > because it might have the same neuroprotective effect for > PWP,s. I am not sure but I > remember that for the trials to come, starting PWP's have > been asked to participate, so > the only outcome of the research will be about its > neuroprotective effect. > I regret that, because I am more interested in its potential > anti-diskinetic power. > <?fontfamily><?param Times New Roman><?bigger>Next to the > mentoned effects is Riluzole, if used in higher dosis a > paini killer a tranquiliser and an anti -convulsive. > With theses URL.s more info can be retrieved, > ida > > http://parkinson.org/plll.htm > > WWW.rorer.com/PATIENTS_FAMILIES/trials/trials.rilutek.htm > > http://www.rpr.rpna.com/US/rilutek/ppi.html > > http://www.druginfonet.com/rilutek.htm > > http://neuro-www.mgh.harvard.edu/forum/ALSF/11.13.9812.56PMRilutek.html > > http://www.rpr.rpna.com/health_professionals/diseaseaware/rilutek.htm > > <?/bigger><?/fontfamily> > > -------------------------------------------------------------- > Vriendelijke Groeten / Kind regards, > > Ida Kamphuis mailto: [log in to unmask]