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Hi, Brian, you wrote: > First, I think that what you are experiencing is not Dyskinesia. - > Dyskinesia is the brain's reaction to excess levodopa , but you are not > taking enough Sinemet to provoke that reaction. > > Bearing in mind that you are 5 yrs into PD, (and maybe earlier symptoms? > your problem is not enough Sinemet! and I think your symptoms are plain > old Vanilla flavoured PD tremor. ****** I know you are the expert on Sinemet and I've read your program, but from what I once read in one of the national newsletters and from my own experience, I don't believe it's necessary to take large amounts of Sinemet to get dyskinesia. I, too, get middle and end of dose dyskinesia. It is definitely not tremor, nor do I have it when I am totally off. I have been on Sinemet for about 9 years. Along with Eldepryl, Amantadine, and Mirapex, I take 1/2 of 25/100 in the a.m. and 3 hrs. later 1 25/100 CR which lasts about 4 hours when I take another that usually holds me until I go to bed. It is a balancing act and you may be right about shortening the dosage time to avoid the end of dose effects. Frustrating!!! Thanks for all your postings. nina