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On Sun 11 Apr, E. Jack Savely wrote: > Hello Jack, thanks for replying; We seem to be generating a little more interest now. First I apologise for accusing you of using the big boot type of dosage of Sinemet - Clearly, you do not. In fact, I suspect that you are in an area where a little change is indicated.: There are certain milestones along the Sinemet trail, namely 1/ the popint where the amount of Sinemet required to stop the tremor, exceeds the level which causes Dyskinesias. In the days when levodopa was the only really effective drug, that would be the end of the usefulness of levodopa. However, this is where the Dopamine agonists make their entry. 2/ The point where the Dopamine Agonists, combined with Levodopa, cannot control the tremor, without causing Dyskinesias. The limit of this region is not yet defined - It depends on the maximum safe dose of agonist. The agonist which I have been using for the last 6 or so years is Pergolide (Permax). The maximum safe dose of agonists is in effect being defined on the hoof by a few people who have no real choice. In my case, I am up to 5 mg per day of Permax, but I am told that some people has gone beyond 12 mg which I find comforting. The important point to remember is that if you have passed point 1/ as I suspect Jeanette has, you can only tolerate a certain amount of levodopa. In my case, it is 37 mg per hour. If I take more than 37mg/hr I cannot control the resulting Dyskinesia by taking more agonist. what you must do is back off your levodopa to the point where you do not get Dyskinesias, then increase the agonist until the tremors stop. Over the coming years, as you continue to lose the dopamine producing cells, you need more agonist, but do not gulp the lot, only take as much as you must and review the situation eery 6 months. Regards, By the way Jack, are you aware that all your messages come through on my internet programme with double-spaced lines? (No one else does that!) -- Brian Collins <[log in to unmask]>