hi all At 03:59 1999/04/14 EDT, helen wrote: >Does anybody on the list have experience with stopping use of Permax? >My husband has been taking Permax for 4 years at a dosage of 1.5mg per >day. Everytime he stops taking Permax, he cannot sleep for days. We are >interested to know how long the sleep disorder lasts given his chronic >use of the drug. as i understand it it can take one week for a healthy human's brain/body to fully adjust to a one hour time zone change no drugs involved just our own bio-chemistry we are a miracle of micro bio electro chemical inter-actions after whew 15 years of playing this game i am convinced more and more as time goes on that tweaking and fine-tuning our brain chemisty needs to be done with a feather's touch and at a snail's pace 'low and slow' is what i was told at the starting gate in order to avoid 'titration trauma' i have noted that to be considered as a guinea pig for any pd med trial we need to be 'drug-free' of whatever the study specifies for count'em three that's three months yep i said months as a gut reaction? if i can 'feel' the difference a med change makes to my body/brain i figure the change has been too much and too fast it seems to me that heavy handed med titration whether up or down is the equivalent of smacking the side of a sluggish television set but the results can be far more devastating than missing an episode of "ER" janet janet paterson - 52 now /41 dx /37 onset - [log in to unmask] 613/256/8340 - po box 171/almonte/ontario/k0a 1a0/canada Scan some of My Past Posts at: http://www.newcountry.nu/pd/members/janet/index.htm Mine the PD List Archives at: http://james.parkinsons.org.uk/ Cull Nine Million Pub-Med Medical Studies at: http://www.ncbi.nlm.nih.gov/PubMed/ Comb the 'People With Parkinson's' Web-Ring at: http://www.webring.org/cgi-bin/webring?ring=parkie;list